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This Special Session will investigate innovative applications of Time Sensitive Networking (TSN) technologies and standards. Emerging distributed computing, monitoring, data acquisition, and measurement systems are heavily reliant on wired and wireless real-time communications, allowing for seamless, standardized, and transparent device integration. In this context, Time Sensitive Networking provides a set of features capable of supporting a wide range of time-critical applications from the bottom of the automation pyramid all the way up to the edge and cloud computing. TSN can be seen as a toolbox that can be configured to enable accurate time synchronization and deterministic latency meeting time-critical requirements. TSN has applications across multiple markets segments and segment specific profiles have been (or are being) developed. For example, a TSN profile is being developed by the IEEE/IEC 60802 group for Industrial Automation and a profile for Audio Video Bridging systems has been developed by Avnu Alliance. Nevertheless, TSN capabilities are not limited to those application domains only. TSN capabilities to deliver time and timeless with high configurability can benefit a broader range of applications that, actually, need to be further investigated. For example, extended reality (XR), financial systems, safety-critical systems, sensors networks, and time-critical systems in industrial, robotics, avionics, aerospace, and automotive applications can benefit from the features of TSN-based Wired, Wireless, or hybrid communication networks, but they are also expected to bring new challenges. This special session will bring together case studies, prototypes, implementations, testing best practices, and innovative applications and challenges for TSN enabled by the latest wired/wireless communications and computing technologies.